Research summary
Research HubGH 191AA (Somatropin)
Clinical — 10 studies
Somatropin is a recombinant form of human growth hormone composed of 191 amino acids, identical to endogenous pituitary growth hormone and extensively studied in endocrine research.
Being studied for
- Growth hormone deficiency research
- IGF-1 signaling pathways
- Metabolic and body composition studies
Published Research
Evidence profile
Human Phase 3 evidence
10 cited publications · 2 primary trials
Findings below belong to the studies that reported them. They describe the material and conditions those authors used, not this product, and not an outcome to expect.
Supporting evidence
Efficacy and Safety of Weekly Somatrogon vs Daily Somatropin in Children With Growth Hormone Deficiency: A Phase 3 Study
Deal CL et al. · The Journal of clinical endocrinology and metabolism · 2022
The study reportedThe efficacy of once-weekly somatrogon was noninferior to once-daily somatropin, with similar safety and tolerability profiles. (ClinicalTrials.gov no. NCT02968004).
Weekly Lonapegsomatropin in Treatment-Naïve Children With Growth Hormone Deficiency: The Phase 3 heiGHt Trial
Thornton PS et al. · The Journal of clinical endocrinology and metabolism · 2021
The study reportedThe trial met its primary objective of noninferiority in AHV and further showed superiority of lonapegsomatropin compared to daily somatropin, with similar safety, in treatment-naïve children with GHD.
Comparison between long-acting pegylated and daily recombinant human growth hormone for pediatric growth hormone deficiency a systematic review
Zhang J et al. · Scientific reports · 2025
The study reportedPEG-rhGH showed superior efficacy to DGH at 12 months and comparable efficacy at other time points. The safety profiles were similar for the two treatments.
Global trends in recombinant human growth hormone for the treatment of idiopathic short stature: a bibliometric analysis
Ouyang R et al. · Frontiers in medicine · 2025
The study reportedThis bibliometric analysis highlights the progression of rhGH research for ISS, shifting from foundational studies to contemporary priorities such as tailored therapies and clinical outcomes.
Recombinant human growth hormone for children born small for gestational age: meta-analysis confirms the consistent dose-effect relationship on catch-up growth
Crabbé R et al. · Journal of endocrinological investigation · 2008
The study reportedThere is a clear dose-response relationship for r-hGH in the treatment of short children born SGA and the analysis confirmed that treatment with Serono r-hGH formulation 0.033 mg/kg/day should provide a meaningful therapeutic response.
Additional indexed literature (5)
- Clinical · Mechanistic studySafety and Efficacy of Pediatric Growth Hormone Therapy: Results From the Full KIGS Cohort
Maghnie M et al. · The Journal of clinical endocrinology and metabolism · 2022 · PMID 36102184
- Clinical · Mechanistic studySomatropin therapy in italian adults with growth hormone deficiency
Pricci F et al. · BMC endocrine disorders · 2022 · PMID 35241041
- Clinical · Mechanistic studyGonadotropin-releasing hormone analogue and recombinant human growth hormone treatment for idiopathic central precocious puberty in girls
Shi Y et al. · Frontiers in endocrinology · 2022 · PMID 36589818
- Preclinical · Mechanistic studyRecombinant human growth hormone and brain neoplasm association: a pharmacovigilance and Mendelian randomization analysis based on US FAERS, Japanese JADER, and Canadian CVARD
Huang L et al. · Frontiers in pharmacology · 2025 · PMID 40799818
- Preclinical · Mechanistic studyMetabolic factors influencing the efficacy of recombinant human growth hormone therapy in children with short stature
Zhong X et al. · Frontiers in endocrinology · 2025 · PMID 41282298
Published studies summarised here concern the specific investigational or pharmaceutical materials and study conditions described by their authors. Their findings are not performance claims for Cobalt Peptides material. Citations verified against PubMed on 2026-08-09.
Somatropin is a prescription-only medicine in many jurisdictions and is presented here solely in a scientific research context.
Notice
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