Research summary
Research HubN-Acetyl Epitalon Amidate
Clinical — 10 studies
N-Acetyl Epitalon Amidate is a modified Epitalon analogue explored in peptide stability and longevity research models.
Being studied for
- Peptide stability research
- Cellular aging mechanisms
Published Research
Evidence profile
Controlled human evidence
10 cited publications · 1 primary trial
Findings below belong to the studies that reported them. They describe the material and conditions those authors used, not this product, and not an outcome to expect.
Supporting evidence
Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa
Khavinson V et al. · Neuro endocrinology letters · 2002
The study reportedEpitalon therapy in patients with degenerative retinal lesions results in a positive clinical effect in 90% of the cases. The analysis of Epitalon effects suggests that the tetrapeptide participates in the mechanisms of transcription common for the epiphysis and retina.
Additional indexed literature (9)
- Review · ReviewOverview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties
Araj SK et al. · International journal of molecular sciences · 2025 · PMID 40141333
- Preclinical · Mechanistic studyEpitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
Al-Dulaimi S et al. · Biogerontology · 2025 · PMID 40908429
- Preclinical · Mechanistic studyThe Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy
Gatta M et al. · Stem cell reviews and reports · 2025 · PMID 40493162
- Preclinical · Mechanistic studyEpitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development
Ullah S et al. · Life sciences · 2025 · PMID 39788414
- Preclinical · Mechanistic studyEpitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro
Yue X et al. · Aging · 2022 · PMID 35413689
- Preclinical · Mechanistic studyAEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism
Khavinson V et al. · Molecules (Basel, Switzerland) · 2020 · PMID 32019204
- Preclinical · Mechanistic studyShort Peptides Protect Oral Stem Cells from Ageing
Sinjari B et al. · Stem cell reviews and reports · 2020 · PMID 31677028
- Preclinical · Mechanistic studyEffects of intranasal administration of epitalon on neuron activity in the rat neocortex
Sibarov DA et al. · Neuroscience and behavioral physiology · 2007 · PMID 17955380
- Preclinical · Mechanistic studyEffect of vilon and epithalon on activity of enzymes in epithelial and subepithelial layers in small intestine of old rats
Khavinson VKh et al. · Bulletin of experimental biology and medicine · 2002 · PMID 12660839
Published studies summarised here concern the specific investigational or pharmaceutical materials and study conditions described by their authors. Their findings are not performance claims for Cobalt Peptides material. Citations verified against PubMed on 2026-08-09.
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