Research summary
Research HubLEMON BOTTLE (Riboflavin, Bromelain, Lecithin)
Clinical — 10 studies
LEMON BOTTLE is a formulation containing riboflavin, bromelain, and lecithin, explored in cosmetic and adipose tissue research contexts.
Being studied for
- Localized adipose tissue research
- Cosmetic formulation studies
Published Research
Evidence profile
Component evidence only — this formulation has not itself been studied
10 cited publications · 2 primary trials
LEMON BOTTLE (Riboflavin, Bromelain, Lecithin) has not itself been studied in the published literature. The studies below examined its individual components and are labelled accordingly: Lecithin / phosphatidylcholine, Riboflavin, Bromelain. Findings belong to the component named on each card, not to this formulation.
Supporting evidence
Tissue-toxic effects of phosphatidylcholine/deoxycholate after subcutaneous injection for fat dissolution in rats and a human volunteer
Schuller-Petrovic S et al. · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2008
The study reportedInjection lipolysis with PC/DC causes tissue fibrosis and necrosis of adipose and vascular tissues in rat and man, making the long-term safety of PC/DC for nonsurgical treatment of subcutaneous fat deposits uncertain.
Fat tissue after lipolysis of lipomas: a histopathological and immunohistochemical study
Bechara FG et al. · Journal of cutaneous pathology · 2007
The study reportedLipolysis with PDC results in a distinct inflammatory reaction of affected fat tissue, similar to factitial panniculitis. Early destruction of fat cells may suggest the involvement of detergent or osmotic mechanisms in the process.
Effects of deficiency or supplementation of riboflavin on energy metabolism: a systematic review with preclinical studies
da Silva-Araújo ER et al. · Nutrition reviews · 2025
The study reportedThis review concludes that riboflavin regulates energy metabolism by activating primary metabolic pathways and is involved in energy balance homeostasis.
Bromelain-Based Enzymatic Debridement Versus Standard of Care in Deep Burn Injuries: A Systematic Review and Meta-Analysis
De Freitas LR et al. · Journal of burn care & research : official publication of the American Burn Association · 2025
The study reportedBromelain-based enzymatic debridement may accelerate eschar removal and reduce the need for surgical excision and autografts, without adversely affecting wound closure time or long-term scar quality.
Efficacy and safety of bromelain: A systematic review and meta-analysis
Leelakanok N et al. · Nutrition and health · 2023
The study reportedConclusions: Moderate-quality studies demonstrated the potential of oral bromelain in pain control and topical bromelain in wound care. Major health risks were not reported during the treatment with bromelain.
Oral Bromelain for the Control of Facial Swelling, Trismus, and Pain After Mandibular Third Molar Surgery: A Systematic Review and Meta-Analysis
Liu S et al. · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2019
The study reportedBromelain conferred moderate relief of postoperative discomfort after third molar surgery.
Is bromelain effective in controlling the inflammatory parameters of pain, edema, and trismus after lower third molar surgery? A systematic review and meta-analysis
de Souza GM et al. · Phytotherapy research : PTR · 2019
The study reportedThe results suggest that the bromelain appears to be effective in the control of pain, edema, and trismus after lower third molar surgeries; however, further high-quality studies are needed to confirm this finding.
Additional indexed literature (3)
- Preclinical · Mechanistic study· Evidence for RiboflavinVitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis
Deol KK et al. · Nature structural & molecular biology · 2026 · PMID 41826758
- Preclinical · Mechanistic study· Evidence for RiboflavinDevelopmental riboflavin deficiency results in structural and functional changes in the neural retina and RPE
Zhao X et al. · Redox biology · 2025 · PMID 40684659
- Preclinical · Mechanistic study· Evidence for RiboflavinFlavin-deficient erythrocytes offer protection against malaria parasites
Hemasa A et al. · Proceedings of the National Academy of Sciences of the United States of America · 2025 · PMID 40854132
Published studies summarised here concern the specific investigational or pharmaceutical materials and study conditions described by their authors. Their findings are not performance claims for Cobalt Peptides material. Citations verified against PubMed on 2026-08-09.
LEMON BOTTLE is presented in the context of cosmetic and formulation research and is not a medicinal product.
Notice
All information on this page is provided strictly for laboratory research and educational purposes only.