Scientific Reference

5-Amino-1MQ

Evidence profile: Predominantly preclinical

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), developed for metabolic and longevity-focused research. By targeting a key regulatory enzyme involved in NAD+ metabolism, it has been investigated for its ability to enhance cellular energy production and mitochondrial efficiency. The compound is primarily explored in the context of metabolic health, body composition, and age-related cellular decline. Preclinical research suggests that modulation of NNMT activity may influence adiposity, insulin sensitivity, and mitochondrial biogenesis, making it of interest in both obesity and longevity research domains.