Scientific Reference

Sermorelin

Evidence profile: Preclinical, with limited uncontrolled human reports

Sermorelin is a synthetic peptide corresponding to the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH 1–29), representing the shortest fully biologically active fragment. It functions as a physiologic stimulator of endogenous growth hormone (GH) secretion by acting on the anterior pituitary. Unlike exogenous GH administration, sermorelin preserves the natural pulsatile release of growth hormone, maintaining regulatory feedback mechanisms and reducing the risk of supraphysiological exposure. It is widely used in research contexts investigating growth hormone axis modulation, recovery, and metabolic regulation.