Scientific Reference

Phosphate Buffered Saline

Evidence profile: Component evidence only — this formulation has not itself been studied

Phosphate Buffered Saline (PBS) is a sterile, isotonic buffer solution composed of sodium chloride, sodium phosphate, and, in some formulations, potassium salts. It is widely used in biological and biochemical research to maintain physiological pH and osmolarity, providing a stable environment for peptides, proteins, and cells. PBS is not a bioactive compound but functions as a carrier and stabilisation medium, commonly used for dilution, washing, and reconstitution in laboratory and research settings. Its compatibility with biological systems makes it a standard solution for maintaining structural integrity and preventing osmotic stress.