Scientific Reference
Melatonin
Evidence profile: Review literature
Melatonin is an endogenous indoleamine hormone derived from tryptophan, primarily synthesised in the pineal gland. It plays a central role in regulating circadian rhythms, particularly the sleep–wake cycle, by responding to light–dark signals. In research settings, melatonin is widely used to study sleep regulation, chronobiology, antioxidant activity, and neuroendocrine function. Beyond its role in circadian signalling, melatonin exhibits potent antioxidant properties and influences mitochondrial function and cellular protection pathways.
Published Research
Melatonin Use in the ICU: A Systematic Review and Meta-Analysis
Tang BHY et al. · Critical care medicine · 2025 · Review
PMID 40662882 — View on PubMedMelatonin as a Novel Drug to Improve Cardiac Function and Quality of Life in Heart Failure Patients: A Systematic Review and Meta-Analysis
Daliri AS et al. · Clinical cardiology · 2025 · Review
PMID 40026259 — View on PubMedInterventions for insomnia in cancer patients and survivors-a comprehensive systematic review and meta-analysis
Nissen ER et al. · JNCI cancer spectrum · 2024 · Review
PMID 38781520 — View on PubMedNeonatal magnesium sulphate for neuroprotection: A systematic review and meta-analysis
Shepherd E et al. · Developmental medicine and child neurology · 2024 · Review
PMID 38468452 — View on PubMedEffect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials
Ziaei S et al. · Journal of ovarian research · 2024 · Review
PMID 38965577 — View on PubMedOptimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose-Response Meta-Analysis
Cruz-Sanabria F et al. · Journal of pineal research · 2024 · Review
PMID 38888087 — View on PubMed