Scientific Reference

Melanotan II (MT-II)

Evidence profile: Human Phase 1 evidence

Melanotan II (MT-II) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that activates multiple melanocortin receptors (MC1R, MC3R, MC4R, MC5R). It was originally developed as a sunless tanning agent but is also associated with effects on sexual arousal and appetite regulation due to broader receptor activity. Unlike Melanotan I, MT-II is non-selective across melanocortin receptors, resulting in both pigmentation effects and systemic neurological and metabolic effects. It produces rapid tanning, often without UV exposure, though minimal UV exposure enhances results.