Cobalt PeptidesResearch Grade

Scientific Reference

Lipo-C (MIC + B Vitamins)

Evidence profile: Component evidence only — this formulation has not itself been studied

Lipo-C is a blend of methionine, inositol and choline (MIC) with B vitamins, including vitamin B12; none of its components is a peptide. Methionine is an essential sulphur-containing amino acid, inositol a cyclic sugar alcohol, choline a small quaternary ammonium nutrient, and vitamin B12 (cobalamin) a corrinoid cofactor. Each ingredient has a long literature of its own in nutrition and biochemistry, drawn from cell, animal and human studies. The blend has none: no published study appears to have examined these components supplied together, so nothing reported for any single ingredient can be carried over to the mixture.

Mechanism of Action

The ingredients meet in methyl-group (one-carbon) metabolism. Methionine is converted to S-adenosylmethionine, the main methyl donor for cellular methylation reactions; once it has given up its methyl group, the product is broken down to homocysteine. Homocysteine can be turned back into methionine by two routes: methionine synthase, which depends on vitamin B12 as methylcobalamin, and a second enzyme that uses betaine, made in cells by oxidising choline. Choline is also the precursor of phosphatidylcholine, a major phospholipid of cell membranes and lipoproteins, and of the neurotransmitter acetylcholine. Inositol is built into phosphatidylinositol and the inositol phosphates used in intracellular signalling. These are features of normal biochemistry, not findings for the blend.

Molecular Information

  • Type: Multi-component blend

Published Research

  • Comparison of myo-inositol and metformin on glycemic control, lipid profiles, and gene expression related to insulin and lipid metabolism in women with polycystic ovary syndrome: a randomized controlled clinical trial

    Shokrpour M et al. · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2019 · Clinical · Evidence for Inositol

    PMID 30608001 — View on PubMed

  • Effects of rumen-protected methionine and choline supplementation on the preimplantation embryo in Holstein cows

    Acosta DAV et al. · Theriogenology · 2016 · Clinical · Evidence for Methionine

    PMID 26928647 — View on PubMed

  • Modulatory role of D-chiro-inositol (DCI) on LH and insulin secretion in obese PCOS patients

    Genazzani AD et al. · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2014 · Clinical · Evidence for Inositol

    PMID 24601829 — View on PubMed

  • Effects of methionine and betaine supplementation on growth performance, carcase composition and metabolism of lipids in male broilers

    Zhan XA et al. · British poultry science · 2006 · Clinical · Evidence for Methionine

    PMID 17050102 — View on PubMed

  • Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial

    Eussen SJ et al. · Archives of internal medicine · 2005 · Clinical · Evidence for Vitamin B12

    PMID 15911731 — View on PubMed

  • Effects of nutrition on metabolic and endocrine outcomes in women with polycystic ovary syndrome: an umbrella review of meta-analyses of randomized controlled trials

    Moslehi N et al. · Nutrition reviews · 2023 · Review · Evidence for Inositol

    PMID 36099162 — View on PubMed