Scientific Reference

Kisspeptin

Evidence profile: Predominantly preclinical

Kisspeptin is a family of neuropeptides encoded by the KISS1 gene, acting as an upstream regulator of the reproductive axis through potent stimulation of gonadotropin-releasing hormone (GnRH) neurons. Several active isoforms are derived from a 145-amino acid precursor; kisspeptin-54 is the predominant circulating form and kisspeptin-10 the minimal fragment retaining full receptor binding. It is studied in reproductive endocrinology on that basis. Supplied strictly as a research compound for laboratory use.