Scientific Reference
GHRP-2
Evidence profile: Controlled human evidence
GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide belonging to the growth hormone secretagogue (GHS) class. It stimulates the release of endogenous growth hormone (GH) primarily through activation of the ghrelin receptor (GHS-R1a) in the hypothalamus and pituitary. Unlike GHRH analogs, GHRP-2 acts via a distinct pathway, making it highly synergistic when combined with GHRH-based peptides. It is widely used in research to investigate growth hormone pulsatility, appetite signalling, and metabolic regulation.
Published Research
The combined administration of GH-releasing peptide-2 (GHRP-2), TRH and GnRH to men with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with GHRP-2 alone
Van den Berghe G et al. · Clinical endocrinology · 2002 · Clinical
PMID 12030918 — View on PubMedSynergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise
Wideman L et al. · American journal of physiology. Regulatory, integrative and comparative physiology · 2000 · Clinical
PMID 11004017 — View on PubMedGrowth hormone-releasing peptide-2 infusion synchronizes growth hormone, thyrotrophin and prolactin release in prolonged critical illness
Van den Berghe G et al. · European journal of endocrinology · 1999 · Clinical
PMID 10037246 — View on PubMedTreatment effects of intranasal growth hormone releasing peptide-2 in children with short stature
Pihoker C et al. · The Journal of endocrinology · 1997 · Clinical
PMID 9390009 — View on PubMed