Scientific Reference

Dermorphin

Evidence profile: Predominantly preclinical

Dermorphin is a naturally derived heptapeptide originally isolated from the skin of South American tree frogs (Phyllomedusa species). It is a highly potent and selective μ-opioid receptor agonist, exhibiting significantly greater affinity and efficacy than endogenous opioid peptides such as endorphins. A unique structural feature of dermorphin is the presence of a D-alanine residue, which enhances receptor binding affinity and resistance to enzymatic degradation. In research settings, dermorphin is used to study opioid receptor signalling, pain modulation pathways, and peptide-receptor interactions.