Cobalt PeptidesResearch Grade

Scientific Reference

BPC-157

Evidence profile: Preclinical, with limited uncontrolled human reports

BPC-157 is a synthetic 15-residue peptide whose sequence was taken from a larger protein reported in human gastric juice. That parent protein, named body protection compound, is described mainly in the papers of the group that reported it, and the peptide is known almost entirely through its own studies. Most published work comes from that single research group and is in rodents, covering models of tendon, ligament, muscle and bone injury, lesions of the stomach and intestine, and some nervous-system models. Human data are very limited, consisting of a few small reports rather than controlled trials. Independent replication outside the originating group is limited.

Mechanism of Action

No receptor for BPC-157 has been identified. Rodent and cell studies have reported changes in several signalling systems, most often the nitric oxide system, VEGF receptor 2 signalling in endothelial cells, and the FAK–paxillin pathway in cultured tendon fibroblasts. Other papers describe interactions with dopamine and serotonin systems in animal models. Several studies have also examined growth-factor and early-response gene expression in injured tissue. Because many of these findings come from a small number of laboratories, using different models, the mechanism is best regarded as unsettled rather than as a known pathway.

Molecular Information

  • Type: Pentadecapeptide
  • Length: 15 amino acids
  • Molecular weight: 1419.5 g/mol
  • Molecular formula: C62H98N16O22
  • CAS: 137525-51-0

Published Research

  • Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians

    Mayfield CK et al. · The American journal of sports medicine · 2026 · Review

    PMID 41476424 — View on PubMed

  • From Regeneration to Analgesia: The Role of BPC-157 in Tissue Repair and Pain Management

    Yuan C et al. · International journal of molecular sciences · 2026 · Review

    PMID 41898733 — View on PubMed

  • Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study

    Lee E et al. · Alternative therapies in health and medicine · 2024 · Clinical

    PMID 39325560 — View on PubMed

  • Protective effects of BPC 157 in rats with experimentally induced lower extremity ischemia-reperfusion injury

    Yıldırım AK et al. · Scientific reports · 2026 · Preclinical

    PMID 42204242 — View on PubMed