Scientific Reference
Bacteriostatic Water
Evidence profile: Component evidence only — this formulation has not itself been studied
Bacteriostatic Water is a sterile, non-pyrogenic water preparation containing 0.9% benzyl alcohol, which acts as a bacteriostatic preservative. It is widely used in research and laboratory settings for the reconstitution and dilution of peptides and other injectable compounds requiring multi-use handling. Unlike sterile water, bacteriostatic water inhibits microbial growth, allowing for repeated withdrawals from the same vial over a defined period. It is the standard solvent for peptide reconstitution when stability, sterility, and extended usability are required.
Published Research
Antimicrobial Preservatives for Protein and Peptide Formulations: An Overview
Stroppel L et al. · Pharmaceutics · 2023 · Review · Evidence for Benzyl alcohol (bacteriostatic preservative)
PMID 36839885 — View on PubMedCritical Aspects of pH Measurement for Bacteriostatic Water for Injection
Hu J et al. · Journal of pharmaceutical sciences · 2023 · Preclinical · Evidence for Benzyl alcohol (bacteriostatic preservative)
PMID 36870668 — View on PubMedMolecular Mechanism of Antimicrobial Excipient-Induced Aggregation in Parenteral Formulations of Peptide Therapeutics
Li M et al. · Molecular pharmaceutics · 2022 · Preclinical · Evidence for Benzyl alcohol (bacteriostatic preservative)
PMID 35917158 — View on PubMedComplex poisoning mainly with benzyl alcohol complicated by paralytic ileus: a case report
Fukuda H et al. · International journal of emergency medicine · 2022 · Preclinical · Evidence for Benzyl alcohol (bacteriostatic preservative)
PMID 35787785 — View on PubMedIncompatibility of ifosfamide with benzyl-alcohol-preserved bacteriostatic water for injection
Behme RJ et al. · American journal of hospital pharmacy · 1988 · Preclinical · Evidence for Benzyl alcohol (bacteriostatic preservative)
PMID 3369469 — View on PubMed