Research Comparison
Melanotan I (Afamelanotide) vs Melanotan II (MT-II)
A side-by-side research comparison of Melanotan I (Afamelanotide) and Melanotan II (MT-II) drawn from Cobalt Peptides' peptide database records.
Melanotan I (Afamelanotide)
Melanotan I (afamelanotide) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that selectively activates melanocortin-1 receptors (MC1R) to stimulate melanin production. It is clinically available as an implant (SCENESSE®) for specific medical indications, while research-grade injectable forms are studied for pigmentation and photoprotective effects. Subcutaneous administration enables rapid systemic exposure, leading to increased melanin synthesis and enhanced tanning response. Unlike Melanotan II, it is more selective for MC1R, reducing off-target melanocortin effects.
Melanotan II (MT-II)
Melanotan II (MT-II) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that activates multiple melanocortin receptors (MC1R, MC3R, MC4R, MC5R). It was originally developed as a sunless tanning agent but is also associated with effects on sexual arousal and appetite regulation due to broader receptor activity. Unlike Melanotan I, MT-II is non-selective across melanocortin receptors, resulting in both pigmentation effects and systemic neurological and metabolic effects. It produces rapid tanning, often without UV exposure, though minimal UV exposure enhances results.