Research Comparison
Ipamorelin vs Tesamorelin
A side-by-side research comparison of Ipamorelin and Tesamorelin drawn from Cobalt Peptides' peptide database records.
Ipamorelin
Ipamorelin is a selective growth hormone releasing peptide (GHRP) that stimulates endogenous growth hormone (GH) secretion via activation of ghrelin (GHS-R1a) receptors in the pituitary. It is characterized by a highly selective profile, producing GH release without significant stimulation of cortisol or prolactin. This selectivity distinguishes it from earlier GHRPs, making it a preferred compound in research focused on body composition, recovery, sleep, and anti-aging. Its ability to preserve physiological GH pulsatility while minimizing off-target endocrine effects has positioned it as a core peptide in GH optimization protocols.
Tesamorelin
Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH), a 44-amino acid peptide carrying a trans-3-hexenoic acid modification at the N-terminus that confers resistance to enzymatic degradation. It binds the GHRH receptor, and the published literature describes pulsatile growth hormone release and downstream IGF-1 elevation. A licensed medicine containing tesamorelin exists in some jurisdictions and is prescribed by clinicians; the material supplied here is a research compound and is not that medicine.