Research Comparison
AHK-Cu (Copper Tripeptide-3) vs NAD+ (Nicotinamide Adenine Dinucleotide)
A side-by-side research comparison of AHK-Cu (Copper Tripeptide-3) and NAD+ (Nicotinamide Adenine Dinucleotide) drawn from Cobalt Peptides' peptide database records.
AHK-Cu (Copper Tripeptide-3)
AHK-Cu (Copper Tripeptide-3) is a synthetic copper-binding tripeptide composed of alanine, histidine, and lysine complexed with a divalent copper ion (Cu²⁺). It is structurally analogous to GHK-Cu, differing by a single amino acid substitution at the N-terminus, which contributes to its more targeted activity in dermal papilla cells and hair follicles. The compound is primarily investigated for its role in hair growth and skin regeneration. It has demonstrated the ability to stimulate follicular activity, enhance vascular signaling, and modulate pathways associated with hair miniaturization. In addition to hair-focused applications, AHK-Cu supports fibroblast activation and collagen synthesis, contributing to improved skin structure and repair.
NAD+ (Nicotinamide Adenine Dinucleotide)
Nicotinamide Adenine Dinucleotide (NAD+) is an essential coenzyme present in all living cells, playing a central role in energy production, DNA repair, and cellular metabolism. It functions as a key redox carrier, cycling between oxidized (NAD+) and reduced (NADH) states to drive mitochondrial ATP production. NAD+ levels decline significantly with age (up to ~10–50% across tissues), contributing to reduced mitochondrial efficiency, increased oxidative stress, and impaired cellular repair. Injectable NAD+ bypasses oral absorption limitations, providing immediate systemic availability and rapid cellular uptake.