Research Comparison
AHK-Cu (Copper Tripeptide-3) vs Glutathione (GSH)
A side-by-side research comparison of AHK-Cu (Copper Tripeptide-3) and Glutathione (GSH) drawn from Cobalt Peptides' peptide database records.
AHK-Cu (Copper Tripeptide-3)
AHK-Cu (Copper Tripeptide-3) is a synthetic copper-binding tripeptide composed of alanine, histidine, and lysine complexed with a divalent copper ion (Cu²⁺). It is structurally analogous to GHK-Cu, differing by a single amino acid substitution at the N-terminus, which contributes to its more targeted activity in dermal papilla cells and hair follicles. The compound is primarily investigated for its role in hair growth and skin regeneration. It has demonstrated the ability to stimulate follicular activity, enhance vascular signaling, and modulate pathways associated with hair miniaturization. In addition to hair-focused applications, AHK-Cu supports fibroblast activation and collagen synthesis, contributing to improved skin structure and repair.
Glutathione (GSH)
Glutathione (GSH) is a naturally occurring tripeptide composed of glutamate, cysteine, and glycine, often referred to as the body’s primary intracellular antioxidant. It is present in virtually all cells and plays a central role in maintaining redox balance, detoxification, and immune function. Levels of glutathione decline with age and are depleted by oxidative stress, toxins, and disease states. Injectable administration bypasses poor oral bioavailability, enabling rapid elevation of plasma glutathione levels and supporting systemic antioxidant defense and detoxification pathways.