Research Comparison
5-Amino-1MQ vs AOD-9604
A side-by-side research comparison of 5-Amino-1MQ and AOD-9604 drawn from Cobalt Peptides' peptide database records.
5-Amino-1MQ
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), developed for metabolic and longevity-focused research. By targeting a key regulatory enzyme involved in NAD+ metabolism, it has been investigated for its ability to enhance cellular energy production and mitochondrial efficiency. The compound is primarily explored in the context of metabolic health, body composition, and age-related cellular decline. Preclinical research suggests that modulation of NNMT activity may influence adiposity, insulin sensitivity, and mitochondrial biogenesis, making it of interest in both obesity and longevity research domains.
AOD-9604
AOD-9604 is a modified 17-amino acid fragment derived from the C-terminal region of human growth hormone (hGH 176–191), with the addition of an N-terminal tyrosine residue. It was specifically engineered to isolate the lipolytic and anti-lipogenic properties of growth hormone while avoiding its anabolic and endocrine effects. Unlike full-length hGH, AOD-9604 does not bind to the growth hormone receptor, does not elevate IGF-1 levels, and does not impair glucose metabolism. This selective mechanism has made it a focus of research in obesity, fat metabolism, and cartilage repair, offering a more targeted metabolic profile without the systemic hormonal effects associated with growth hormone.