Research Comparison
Aicar vs SLU-PP-332
A side-by-side research comparison of Aicar and SLU-PP-332 drawn from Cobalt Peptides' peptide database records.
Aicar
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide), also known as acadesine, is a synthetic small molecule that functions as an AMP analog and activator of AMP-activated protein kinase (AMPK). It is widely used in metabolic research to study energy homeostasis, glucose regulation, and mitochondrial function. Once inside cells, AICAR is phosphorylated to form ZMP (AICAR monophosphate), which mimics AMP and activates AMPK. This leads to downstream effects on energy metabolism, including increased fatty acid oxidation, improved glucose uptake, and inhibition of anabolic pathways.
SLU-PP-332
SLU-PP-332 is a synthetic small-molecule compound that functions as a pan-estrogen-related receptor (ERR) agonist with preferential activity at ERRα. Often described as an 'exercise mimetic,' it activates metabolic gene expression programmes typically engaged during aerobic exercise without requiring physical activity. By enhancing mitochondrial biogenesis, fatty acid oxidation, and energy expenditure, SLU-PP-332 has demonstrated significant preclinical effects including weight reduction, improved endurance, and reversal of age-related mitochondrial dysfunction. It remains a research-only compound with no human clinical trial data currently available.