Research Comparison
Aicar vs LC120
A side-by-side research comparison of Aicar and LC120 drawn from Cobalt Peptides' peptide database records.
Aicar
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide), also known as acadesine, is a synthetic small molecule that functions as an AMP analog and activator of AMP-activated protein kinase (AMPK). It is widely used in metabolic research to study energy homeostasis, glucose regulation, and mitochondrial function. Once inside cells, AICAR is phosphorylated to form ZMP (AICAR monophosphate), which mimics AMP and activates AMPK. This leads to downstream effects on energy metabolism, including increased fatty acid oxidation, improved glucose uptake, and inhibition of anabolic pathways.
LC120
LC120 is a small molecule compound identified as a pan-estrogen-related receptor (ERR) agonist, targeting ERRα, ERRβ, and ERRγ. It is used in metabolic research to investigate mitochondrial function, energy expenditure, and oxidative metabolism. By activating ERR pathways, LC120 enhances transcriptional programmes associated with mitochondrial biogenesis and fatty acid oxidation. It is particularly relevant in studies focused on endurance, metabolic flexibility, and cellular energy efficiency.