Research Comparison
Adamax vs Selank
Adamax and Selank side by side, each from its own compound record: what it is, how it acts, and the values the record holds.
Selank
Selank is a synthetic seven-residue peptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, made by adding Pro-Gly-Pro to the tetrapeptide tuftsin. Tuftsin is a fragment of the heavy chain of immunoglobulin G, studied in immunology for its actions on phagocytic cells; the Pro-Gly-Pro extension was added to slow enzymatic breakdown. Selank was developed in Russia, and most published work on it comes from Russian groups. That literature consists mainly of rodent behavioural and gene-expression studies, with some small clinical studies, many of them published in Russian-language journals. Independent work outside Russia is limited.
How Selank acts
No single receptor for Selank has been identified. Rodent studies have reported that it changes the expression of genes involved in GABAergic neurotransmission, and some experiments suggest it modulates GABA-A receptor function allosterically. It has also been reported to inhibit enkephalin-degrading enzymes in blood serum, to affect monoamine metabolism in the brain, and to alter the expression of cytokines including interleukin-6. Increased expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus has also been described. Much of this evidence comes from a small number of laboratories and awaits independent replication.
The records side by side
- Type: Adamax, not recorded; Selank, Synthetic tuftsin analog (heptapeptide)
- Length: Adamax, not recorded; Selank, 7 amino acids
- Molecular weight: Adamax, not recorded; Selank, 751.9 g/mol
- Molecular formula: Adamax, not recorded; Selank, C33H57N11O9
Reading a comparison
A comparison places two records side by side; it does not merge them. Each description above is drawn from that compound's own record, and the two were not necessarily characterised by the same methods, at the same time, or to the same level of detail. Before comparing any attribute, it is worth establishing that both records describe the substance you think they describe — names are not identifiers, and two entries sharing a name can differ in salt form, stereochemistry or the convention used to state a mass. Where a figure carries no method beside it, the comparison is between two reported numbers rather than between two measurements.